Chemical:
Idebenone
EXCIPIENTS:
Monohydrate lactose, carboxymethyl cellulose, pre-gelatinized, starch, magnesium stearate, sucrose, titanium dioxide, talc, gum arabic, magnesium carbonate, phtalic polyvinyl acetate.
Properties:
Idebenone is a chemical derivative of benzochinone. Numerous laboratory and volunteer based research tests have shown that Idebenone is able to correct biochemical alterations associated with cerebral suffering. In fact it contrasts with the minimal synthesis of ATP, the minimal use of glucose and the increase of lactic acid. Laboratory test have also shown that Idebenone inhibits lipid peroxidation, protecting the neuronal membrane and the mitochondrions from the damage caused by the lipoperoxide products, used in treating ischaemia. It has finally been demonstrated that Idebenone improves learning time and memory activity in aging experimental animals and in those suffering from cerebral ischaemia. Such an effect is traced back to a positive influence of that carried out in the comparison of the synthesis, and the turnover of serotonin and acetylcholine. Recent clinically controlled studies have confirmed the effectiveness of Idebenone in syndromes involving mental deterioration due to numerous causes, characterized by cognitive- behavioral disturbances (loss of memory, attention span, concentration, and psycho-affective disorders).
Pharmakonetics:
Taken by mouth, Idebenone is quickly absorbed and the maximum plasmatic levels are observed approximately 4 hours following the dosage. The product is metabolized into the hepatic area. Taking the product after the evening meal improves its absorption. Idebenone does not tend to accumulate even when taken over a prolonged period. Experimental date has shown that Idebenone crosses the haemoencephalic barrier and is distributed in significant concentrations at the level of the brain tissue. Elimination normally takes place by means of the kidneys.
Information for the User:
This product is recommended for the treatment of cognitive behavioral loss due to vascular and degenerative cerebral pathologies.
Directions:
Recommended dosage is 1 tablet twice a day after meals.
Warning:
Although studies in animals have shown no harmful effects, this product should not be taken during the first three months of pregnancy and during nursing, only when absolutely necessary and always under a doctor's supervision.
Contraindications:
Individual hypersensitivity to the product.
Side Effects:
Taking this product may cause the following side effects- gastrointestinal disturbances, dizziness, headaches, anxiety, and uneasiness and sleep alterations. There are possible alterations of certain laboratory parameters owing to transaminase and of haemochrome. Such side effects are mild and disappear when treatment is stopped.