Dutasteride (Avodart) Targets Hair Loss and Enlarged Prostates!

Dutasteride (Avodart) was developed by the group GlaxoSmithKline, and is an FDA approved drug.  It is in a class of drugs called 5-alpha reductase inhibitors.  It was developed for treating benign prostatic hyperplasia (BPH), or enlarged prostate, and acts by blocking the production of a natural substance that enlarges the prostate gland.

In treating prostate conditions with Dutasteride, patients have noted improved symptoms of BPH, and a reduced incidence of acute urinary retention.

Other Benefits

Clinical research has also discovered that Dutasteride is effective in treating male pattern hair loss.  Studies concluded that men who suffer from male pattern hair loss or BPH have increased levels of the hormone dihydrotestosterone (DHT).

DHT is a by-product of testosterone and is produced by an enzyme called 5-alpha-reductase.  Biochemical analyses reveal that men who suffer BPH appear to have higher levels of 5-alpha-reductase in their bloodstreams and in their scalps.  Conversely, less of this enzyme is found in men who do not suffer with BPH or male pattern hair loss.

By blocking the type I and type II enzymes that form DHT, Dutasteride inhibits 5-alpha-reductase. The blocking action disrupts a key process in the development of male pattern hair loss, and in development of BPH.

In March, 2007, the Journal of Cosmetic Dermatology, printed the results of a study comparing the effectiveness of Dutasteride vs. a placebo in patients with male pattern hair loss (or androgenetic alopecia).  The trial, which was a randomized, double-blind placebo controlled, single center study, involved 17 pairs of identical twin males over a 12 month period.   One twin from each pair was given a 0.5mg dose Dutasteride while the other received a placebo.  Hair counts, photographs and self-assessment questionnaires were used to evaluate the rate of hair growth.  At the conclusion of the 12 month period and based on analysis of the evaluating criteria, it was established that Dutasteride significantly improved hair growth compared with the placebo.  The Journal thus suggested that the trial provided evidence enough to demonstrate that Dutasteride significantly reduced the progression of hair loss in men suffering with male pattern baldness.

Male patient before treatment with Dutasteride.	Male patient after 24 weeks of Dutasteride treatment.

Note:
DHT levels can be monitored using the hormone test kit.

Caution:
Dutasteride is a 5-alpha reductase inhibitor and therefore must not be handled or used by women.

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