Articles under Metformin


  • The Crosslinkage Theory of Aging

    The Crosslinkage Theory of Aging was first proposed by Dr. Johan Bjorksten in 1941. Bjorksten believed that aging was caused by inter- and intra-molecular crosslinks in proteins, nucleic acids, and other vital macromolecules that caused them to gradually “stiffen” and lose their function.1 Bjorksten initially searched for enzymes capable of “dissolving” damaging crosslinks. But as he grew older he realized that he didn’t have enough years of life ahead of him to a...
  • AMPK: a complicated metabolic signalling pathway

    Cellular homoeostasis is a crucial prerequisite for health and good function. Although the study of all the mechanisms involved in maintaining homoeostasis is extremely complicated and confusing, it is nevertheless possible to examine certain processes which play an important role in the orchestration of events designed to maintain efficient cell function. One such process is the role of AMPK (5' adenosine monophosphate-activated protein kinase), an enzyme which is present both in lower (yeas...
  • Why diets don’t work

    Why diets don’t work By Dr. Sergey A. Dzugan   Millions of people seek diets and treatments for being overweight and obese. For most people, weight management is not effective, since the majority of them lose the struggle to reduce weight and blame themselves for the relapse.1 Perhaps the most frequent question that I have been asked over the last 20 years is “How can I lose weight?” In Latin diet (dieta) is a manner of livin...
  • Why Do Women Live Longer Than Men?

    It is a known fact that, in general, women live longer than men. All life expectancy calculations over the past years tend to show that females live several years longer compared to males, as a group (see figure 1).   There are several theories trying to explain this phenomenon and some concepts are better supported by research than others. This discussion refers to the rate of aging process in regard to gender and not to the individual perception of aging. In other words, it...
  • Updating the Calorie Restriction Mimetics

    Updating the Calorie Restriction Mimetics When I first started writing about Calorie Restriction Mimetics (CRM) 10 years ago, research in this area was at its infancy. Now however, several CRM are well-known and relatively well-accepted agents which imitate the effects of calorie restriction itself. I highlight the fact that these compounds are not merely pills for those who are too lazy to diet, but may be used (under medical supervision) in association with a healthy lifestyle to ...
  • The ultimate AGE inhibitors

    The ultimate AGE inhibitors We’ve known for several decades that the process of glycosylation is one of the most important causes of aging, perhaps equally as important as the process of oxidation. During our daily metabolism, sugar molecules, (such as glucose and fructose) and reactive aldehydes and/or ketones may combine to any free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called the Maillard reaction. It...
  • The Grim Reaper Came Knocking and I Answered by Correcting my Hormones and Peptides!

    The Grim Reaper Came Knocking and I Answered by Correcting my Hormones and Peptides! By Dr. Richard Lippman Death came calling when I suffered a minor arrhythmia. My damaged youth started when my close friends pushed me aside and sometimes retorted with irritating comments. I hadn’t realized how negative I had become and its unwelcome effects upon my friends. My neurosurgeon colleague diagnosed me with Asperger’s syndrome (a form of autism), but he had only part...
  • Metformin Update

    Metformin Update: Still the Most Effective Anti-Aging, Life Extension Drug, with a Broad Range of Benefits:  Anti-Cancer, Cardioprotective, and Anti-Obesity Metformin (Glucophage ®) is an anti-diabetic biguanide drug which has been available in Europe since 1957, but was not approved in the U.S. until 1995. Metformin is chemically very similar to Phenformin, an anti-diabetic drug which was discontinued in the Un...
  • The Cataract Cure about L-carnosine and N-acetylcarnosine

    The Cataract Cure about L-carnosine and N-acetylcarnosine Dr. Kyriazis is one of Britain’s top anti-aging physicians and is internationally recognised as a pioneer in the field. He is a bio-gerontologist with a medical degree and postgraduate degrees from King’s College, London and the Royal College of Physicians. He has written many books for both ...
  • Taking Supplements - Have We Got It Wrong

    Taking Supplements - Have We Got It Wrong The great majority, or perhaps all of you, reading this Antiaging Magazine take some nutritional supplements or other natural remedies. And it is very likely that you take these supplements at regular intervals, say once every day, or every 8 hours or whatever. This regularity in taking a certain supplement reflects the current, standard advice given by most medical practitioners and covers every prescription drug, supplement or natura...
  • Metformin: The most effective and under-appreciated life extension drug

    Metformin: The most effective and under-appreciated life extension drug Metformin, an anti-diabetic biguanide drug, has recently been introduced in the United States for the treatment of non-insulin dependent diabetes (type II diabetes). In addition to its promise in treating diabetes, metformin may prove to be one of the most promising anti-aging; life extending drugs available! Metformin is chemically very similar to phenformin, an anti-diabetic drug that was disconti...
  • Metformin: As a Safe, Effective Weight Loss Drug

      Metformin: The Most Effective Life Extension Drug is Also a Safe, Effective Weight Loss Drug   Metformin (Glucophage( ®)) is an anti-diabetic biguanide drug which is now available in the United States for the treatment of both Type I diabetes (insulin dependent) as well as Type II (non-insulin-dependent) diabetes. In addition to its dramatic ability to improve the condition of diabetics, ~Metformin is also one of the most promising anti-aging, life extendin...
  • Calorie Restriction Mimetics

    Calorie Restriction Mimetics The most reliable intervention which consistently increases the life-span of animals is calorie restriction (CR). This intervention does not only extend the 'average life-span' (the average number of years an animal is expected to live), but it also prolongs the 'maximum life-span', which is the maximum number of years a particular species can possibly reach. The maximum life-span of mice is 3 years, while that of chimpanzees is 50 years. The human...
  • Synergistic Programs - Weight Control

    Synergistic Programs - WEIGHT CONTROL Stage 1:Acomplia tablets: One 20mg tablet daily of the new blockbuster weight loss drug Acomplia has been shown to reduce body weight on average by 10% without changes to lifestyle habits. Furthermore Acomplia appears to change cardiovascular and diabetic lipid ratios favorably and most importantly appears to be able to remove fat from the waistline, with an average loss of 3-inches in the clinical trials. ...
  • Dr. Dean's most Recommended Anti-aging Medicine

    Dr. Dean's most Recommended Anti-aging Medicine Ward Dean, M.D., is one of the most forthright physicians in the world today who is researching and practising anti-aging medicine. Apart from his groundbreaking work with Professor Vladimir Dilman, in forming the; "Neuroendocrine Theory of Aging and Degenerative Disease," he is also a world renowned expert in; Biological Aging Measurement, having written the magnum opus of the same name. Well known for writin...
  • Cross-link Breakers and Inhibitors

    Cross-link Breakers and Inhibitors It is now well established that the process of glycosylation is one of the most important causes of ageing, perhaps equally as important as the process of oxidation (free radical damage). During everyday metabolism, sugar molecules (such as glucose and fructose), and reactive aldehydes and/or ketones may attach to free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called th...