Articles under Aminoguanidine


  • The Crosslinkage Theory of Aging

    The Crosslinkage Theory of Aging was first proposed by Dr. Johan Bjorksten in 1941. Bjorksten believed that aging was caused by inter- and intra-molecular crosslinks in proteins, nucleic acids, and other vital macromolecules that caused them to gradually “stiffen” and lose their function.1 Bjorksten initially searched for enzymes capable of “dissolving” damaging crosslinks. But as he grew older he realized that he didn’t have enough years of life ahead of him to a...
  • The Role of Glycation in Aging

    Even people who have no training in chemistry or biology, but who are interested in the aging process, have heard of the Maillard reaction. This is a chemical reaction between proteins (specifically, amino acids) and sugar molecules, a process called glycation. The reaction was described for the first time in 1912, and it takes its name from the French chemist Louis-Camille Maillard. Over the years, this reaction has been studied in detail. Among other things, it plays a crucial role du...
  • Why diets don’t work

    Why diets don’t work By Dr. Sergey A. Dzugan   Millions of people seek diets and treatments for being overweight and obese. For most people, weight management is not effective, since the majority of them lose the struggle to reduce weight and blame themselves for the relapse.1 Perhaps the most frequent question that I have been asked over the last 20 years is “How can I lose weight?” In Latin diet (dieta) is a manner of livin...
  • How to Maintain or Even Improve Your Vision as You Age

    How to Maintain or Even Improve Your Vision as You Age Vision may be the most precious of our five senses. Yet most of us may take it for granted...until it begins to deteriorate with age. As we get older we likely need greater amounts of light to perceive details clearly, and reading glasses to discern fine print which would otherwise be fuzzy. Night driving becomes difficult due to sensitivity from bright lights and glare, and it's challenging to visually adapt to the darkness. Th...
  • The ultimate AGE inhibitors

    The ultimate AGE inhibitors We’ve known for several decades that the process of glycosylation is one of the most important causes of aging, perhaps equally as important as the process of oxidation. During our daily metabolism, sugar molecules, (such as glucose and fructose) and reactive aldehydes and/or ketones may combine to any free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called the Maillard reaction. It...
  • An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine

    An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine In order to fight age-related degeneration, many anti-aging physicians and researchers recommend the intake of not one or two agents but a finely tuned combination of several compounds which have a wide spectrum of actions. In this article I am going to discuss my favourite combination of a few selected and pluripotent (i.e. having multiple actions) anti-aging compounds. These...
  • The Cataract Cure about L-carnosine and N-acetylcarnosine

    The Cataract Cure about L-carnosine and N-acetylcarnosine Dr. Kyriazis is one of Britain’s top anti-aging physicians and is internationally recognised as a pioneer in the field. He is a bio-gerontologist with a medical degree and postgraduate degrees from King’s College, London and the Royal College of Physicians. He has written many books for both ...
  • Improving Your Cardiovascular Health And How To Know How Hard Your Arteries Are

    Improving Your Cardiovascular Health And How To Know How Hard Your Arteries Are It’s amazing to think that as long ago as the 17th Century Dr. Thomas Sydenham wrote that; “a man is as old as his artery.”[i] It’s taken the best part of 300 years to prove that he was correct and yet even today arterial health is not as heavily ‘relied upon’ as other cardiovascular markers- for example cholesterol. Perhaps that’s because arterial stiffness measurement has been difficult a...
  • A Patient's Assessment for Anti-Aging Medicine

      A Patient's Assessment for Anti-Aging Medicine By Marios Kyriazis M.D.   Ed.- Dr. Kyriazis is one of the UK's leading Anti-Aging Physicians and the founder and medical advisor to the British Longevity Society. He is also one of the few physician's worldwide who has conducted tests on aging but otherwise healthy individuals and the effective low dose use of L-carnosine, (as reported in the Winter 2001 IAS Anti-Aging Bulletin). Dr. Kyriazis spo...
  • Aminoguanidine: Advanced Glycation End (AGE) Product Inhibitor

    Aminoguanidine: Advanced Glycation End (AGE) Product Inhibitor Aminoguanidine is a promising "new" anti-aging therapy and interest has been aroused by the fact that it may be able to prevent signs of aging before they occur. The glucose cross-linking problem It is believed that the cross-linking of the proteins that make up the human body play a role ...
  • Synergistic Programs - Blood & Heart

    Synergistic Programs - Blood & Heart Stage 1:Endozym-Med: Two tablets 1 or 2 times a day provides the strongest amount of nattokinase (natto) - a Japanese plant. Together along with a number of scientifically corroborated systemic enzymes, Endozym-Med promotes smoother blood flow. As one of America’s leading cardiologists; Kenneth Kensey, M.D. has acknowledged in his book; “the blood thinner cure,” it is blood viscosity that is the single ...
  • Synergistic Programs - Antiaging pack

    Synergistic Programs - Antiaging pack Antiaging is the ultimate preventative medicine As you might expect, antiaging medicine is by definition an incredibly broad subject. The American Academy of Antiaging Medicine (A4M) essentially defines it as the best of all the existing and emerging technologies, which can naturally mean a huge field. Here at IAS, whilst we can accept that there are many approaches to improving aging, from a walk round the block (e.g. exer...
  • Skin Aging: When the dimples become wrinkles

    Skin Aging: When the dimples become wrinkles While all components of the skin are affected by age without exception, some segments are more vulnerable than others. It is well accepted that components of the skin age at different rates and in different degrees. This is because of individual genetic variations, (mosaicism) which are superimposed upon variable external factors and influences such as sun exposure, diet and pollution (1). For example, the skin under the eyes may ap...
  • Cross-link Breakers and Inhibitors

    Cross-link Breakers and Inhibitors It is now well established that the process of glycosylation is one of the most important causes of ageing, perhaps equally as important as the process of oxidation (free radical damage). During everyday metabolism, sugar molecules (such as glucose and fructose), and reactive aldehydes and/or ketones may attach to free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called th...