Articles under Carnosine


  • The Crosslinkage Theory of Aging

    The Crosslinkage Theory of Aging was first proposed by Dr. Johan Bjorksten in 1941. Bjorksten believed that aging was caused by inter- and intra-molecular crosslinks in proteins, nucleic acids, and other vital macromolecules that caused them to gradually “stiffen” and lose their function.1 Bjorksten initially searched for enzymes capable of “dissolving” damaging crosslinks. But as he grew older he realized that he didn’t have enough years of life ahead of him to a...
  • The Role of Glycation in Aging

    Even people who have no training in chemistry or biology, but who are interested in the aging process, have heard of the Maillard reaction. This is a chemical reaction between proteins (specifically, amino acids) and sugar molecules, a process called glycation. The reaction was described for the first time in 1912, and it takes its name from the French chemist Louis-Camille Maillard. Over the years, this reaction has been studied in detail. Among other things, it plays a crucial role du...
  • Telomerase Modulators

    It is true to say that telomeres and telomerase are one of the hottest areas of anti-aging research, but it is also true that the misconceptions and confusion in this area are significant. Here, I will assume that you are already familiar with telomeres and the general function of telomerase. In any case, I will discuss the supplements, nutrients and strategies that can help improve the overall function of telomerase and so result in healthy telomeres, and thus, healthy DNA. This coul...
  • How to Maintain or Even Improve Your Vision as You Age

    How to Maintain or Even Improve Your Vision as You Age Vision may be the most precious of our five senses. Yet most of us may take it for granted...until it begins to deteriorate with age. As we get older we likely need greater amounts of light to perceive details clearly, and reading glasses to discern fine print which would otherwise be fuzzy. Night driving becomes difficult due to sensitivity from bright lights and glare, and it's challenging to visually adapt to the darkness. Th...
  • Exercise Mimetics

    Exercise Mimetics By Marios Kyriazis MD Research into calorie restriction mimetics (drugs which mimic the physiological actions of calorie restriction itself) has opened up interest in other areas, where drugs or compounds may be able to afford the same benefits as the physical action itself. Here, by ‘action’ I mean not only diet, but also exercise or even sex! In a previous IAS publication I discussed calorie restriction mimetics in some detail. Maybe, in the ...
  • The ultimate AGE inhibitors

    The ultimate AGE inhibitors We’ve known for several decades that the process of glycosylation is one of the most important causes of aging, perhaps equally as important as the process of oxidation. During our daily metabolism, sugar molecules, (such as glucose and fructose) and reactive aldehydes and/or ketones may combine to any free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called the Maillard reaction. It...
  • Carnosine Update

    Carnosine Update: New and existing functions of carnosine confirmed by research As many of you may know, one of my favourite nutritional supplements is carnosine. I recognised the potential of this nutrient over 10 years ago and started using it on many of my patients. Carnosine is an all round anti-ageing supplement, as it is an antioxidant, anti-glycator, a chelator of heavy metals (i.e. it inactivates any toxic metal ion...
  • An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine

    An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine In order to fight age-related degeneration, many anti-aging physicians and researchers recommend the intake of not one or two agents but a finely tuned combination of several compounds which have a wide spectrum of actions. In this article I am going to discuss my favourite combination of a few selected and pluripotent (i.e. having multiple actions) anti-aging compounds. These...
  • Interview with Dr Kyriazis about L-carnosine and N-acetylcarnosine

    Interview with Dr Kyriazis about L-carnosine and N-acetylcarnosine Marios Kyriazis M.D. is one of the leading anti-aging physicians in the UK. He is also one of the few researchers who has tested 'low dosages' of L-carnosine in humans for its anti-oxidant abilities. In this interview Dr. Kyriazis elaborates on those results and also upon the emergence of N-acetylcarnosine. Phil: 'Dr. Kyriazis, many thanks for taking time out of your busy schedule to talk to us today about yo...
  • The Cataract Cure about L-carnosine and N-acetylcarnosine

    The Cataract Cure about L-carnosine and N-acetylcarnosine Dr. Kyriazis is one of Britain’s top anti-aging physicians and is internationally recognised as a pioneer in the field. He is a bio-gerontologist with a medical degree and postgraduate degrees from King’s College, London and the Royal College of Physicians. He has written many books for both ...
  • Insomnia cured at last

    Insomnia cured at last Lack of sleep causes weight gain¹ and a host of other health problems² and until 2011, the medical community has only addressed its symptoms with prescription drugs loaded with side effects. For example, five years ago Rep. Robert F. Kennedy Jr. took Ambien® at bedtime, and five hours later, he almost ran down a DC cop thinking it was time to go to work at 3:00 am! Why Treat Symptoms Of Insomnia? Why Not Solve Its Underlying Causes? Other ...
  • HCG Works for Weight Loss (if used correctly)

    HCG Works for Weight Loss (if used correctly) HCG, or human chorionic gonadotropin, is a completely natural substance extracted from the urine of pregnant women. It works by tricking the body into thinking it is pregnant in order to burn off fat and protect muscles for the developing fetus. It is not a hormone; instead, it is classified as a polypeptide, and athletes typically use it to enhance performance by metabolizing fat, especially in the stomach, thighs, and upper arms. Latel...
  • Improving Your Cardiovascular Health And How To Know How Hard Your Arteries Are

    Improving Your Cardiovascular Health And How To Know How Hard Your Arteries Are It’s amazing to think that as long ago as the 17th Century Dr. Thomas Sydenham wrote that; “a man is as old as his artery.”[i] It’s taken the best part of 300 years to prove that he was correct and yet even today arterial health is not as heavily ‘relied upon’ as other cardiovascular markers- for example cholesterol. Perhaps that’s because arterial stiffness measurement has been difficult a...
  • Synergistic Programs - Cardio & Heart Pack

    Don’t miss a beat when it comes to your heart health Cardiovascular disease remains the number one killer of adults despite the focus of attention it has had in terms of lifestyle, diet and exercise information that has been poured onto the general public in the last decade. Those who are aware of the real problems appreciate that too much focus has been placed onto cholesterol and that other blood markers such as homocysteine, C-reactive protein, HbA1C and triglyceri...
  • Carnosine can Reduce Urinary MDA Concentration

    Low Dose Carnosine can Reduce Urinary MDA Concentration Dr. Marios Kyriazis is one of the few anti-aging physicians in the United Kingdom, he is also considered to be an expert on carnosine and has been actively involved in its research over the last few years. Indeed, his lecture at the Second Monte Carlo Antiaging Conference ™ was entitled "Carnosine, the new anti-aging di-peptide," and an audio-cassette is now available for purchase (please see order form or website)....
  • Carnosine - The New Anti-Aging Supplement

      Carnosine - The New Anti-Aging Supplement by Marios Kyriazis M.D.   *Please don't confuse this for the common amino acid CARNITINE (L-Carnitine). Although carnosine (also known as L-carnosine) has been known for about a century, its antiaging properties have only been extensively studied during the past few years. A recent literature review revealed over 780 published studies on carnosine, mainly by Russian and Japanese researchers. However, more wide...
  • A Patient's Assessment for Anti-Aging Medicine

      A Patient's Assessment for Anti-Aging Medicine By Marios Kyriazis M.D.   Ed.- Dr. Kyriazis is one of the UK's leading Anti-Aging Physicians and the founder and medical advisor to the British Longevity Society. He is also one of the few physician's worldwide who has conducted tests on aging but otherwise healthy individuals and the effective low dose use of L-carnosine, (as reported in the Winter 2001 IAS Anti-Aging Bulletin). Dr. Kyriazis spo...
  • Taking Supplements - Have We Got It Wrong

    Taking Supplements - Have We Got It Wrong The great majority, or perhaps all of you, reading this Antiaging Magazine take some nutritional supplements or other natural remedies. And it is very likely that you take these supplements at regular intervals, say once every day, or every 8 hours or whatever. This regularity in taking a certain supplement reflects the current, standard advice given by most medical practitioners and covers every prescription drug, supplement or natura...
  • Skin Aging: When the dimples become wrinkles

    Skin Aging: When the dimples become wrinkles While all components of the skin are affected by age without exception, some segments are more vulnerable than others. It is well accepted that components of the skin age at different rates and in different degrees. This is because of individual genetic variations, (mosaicism) which are superimposed upon variable external factors and influences such as sun exposure, diet and pollution (1). For example, the skin under the eyes may ap...
  • Synergistic Programs - Energy & Sport Pack

    Synergistic Programs - Energy & Sport Pack Being physically active is part of the battle to stay fit, often we all need encouragement to exercise and we also want to see the best possible outcomes from that exercise, after all positive gains are the best incitement to continue to do more. In addition, we have to protect ourselves against the damage induced by aerobic exercise because it generates oxidative free radicals, (primarily through oxygen consumption/ metabolism...
  • Cross-link Breakers and Inhibitors

    Cross-link Breakers and Inhibitors It is now well established that the process of glycosylation is one of the most important causes of ageing, perhaps equally as important as the process of oxidation (free radical damage). During everyday metabolism, sugar molecules (such as glucose and fructose), and reactive aldehydes and/or ketones may attach to free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called th...