Articles by DEAN, M.D., Ward


  • Eugeroics—Viagra® for the brain?

    Adrafinil (Olmifon®/ Adra-Pro™), modafinil (Provigil®/ Moda-Pro™), and armodafinil (Nuvigil®) are three members of a class of drugs known as eugeroic’s (“eugregorique” means “good arousal” in French).1 The term was proposed in 1987 by Jouvet, to characterize the arousal, vigilance-enhancing, anti-depressant effects of adrafinil, the first drug in this class. Adrafinil was developed in France in the late 1970s by Louis Lafon Laboratories. One of the most striking behavioral re...
  • The Crosslinkage Theory of Aging

    The Crosslinkage Theory of Aging was first proposed by Dr. Johan Bjorksten in 1941. Bjorksten believed that aging was caused by inter- and intra-molecular crosslinks in proteins, nucleic acids, and other vital macromolecules that caused them to gradually “stiffen” and lose their function.1 Bjorksten initially searched for enzymes capable of “dissolving” damaging crosslinks. But as he grew older he realized that he didn’t have enough years of life ahead of him to a...
  • Deprenyl and Alzheimer's Disease - Update

    Deprenyl and Alzheimer’s disease—update By Ward Dean, M.D. Deprenyl (aka seligiline, trade names Eldepryl®, Jumex®) was discovered in Hungary in the 1950s and was patented by Professor Jozsef Knoll of Semmelweis University in Hungary in 1962. Deprenyl was shown to extend maximum lifespan in animals, enhance cognition in normal healthy animals, reduce the symptoms and delay the progress of Parkinson’s and Alzheimer’...
  • Metformin Update

    Metformin Update: Still the Most Effective Anti-Aging, Life Extension Drug, with a Broad Range of Benefits:  Anti-Cancer, Cardioprotective, and Anti-Obesity Metformin (Glucophage ®) is an anti-diabetic biguanide drug which has been available in Europe since 1957, but was not approved in the U.S. until 1995. Metformin is chemically very similar to Phenformin, an anti-diabetic drug which was discontinued in the Un...
  • Smart drugs and nutrients, an interview with Ward Dean, M.D.

    Smart drugs and nutrients, an interview with Ward Dean, M.D. Phil Micans interviews Dr. Ward Dean, who is perhaps best known to the public for his two best-selling books on ‘Smart Drugs & Nutrients’ (versions I and II) in the early 1990’s. Dr. Dean graduated from the US Military Academy at West Point in 1967, and served in the Infantry for six years, posted to both Airborne and Ranger forces. He obtained his medical degree from Han Yang University in Korea in 1978, and re...
  • Hypothyroidism - The Underdiagnosed Epidemic

    Hypothyroidism - The Underdiagnosed Epidemic Why physicians won't prescribe its safe inexpensive cure and the dilemma physicians face when prescribing natural thyroid hormone. One of the most common (but often undiagnosed) causes of a variety of seemingly unrelated symptoms, is that of underactive thyroid function, or hypothyroidism. Dr. Broda Barnes, a brilliant, intuiti...
  • Vasopressin- The Anti-aging, Cognitive Enhancing Neuropeptide

    Vasopressin- The Anti-aging, Cognitive Enhancing Neuropeptide Vasopressinis a pituitary hormone that is best known for controlling water balance in the body. Its common name is anti-diuretic hormone (ADH), because of its property of conserving water in the body, and inhibiting urine production. Because of this property, many parents of children with bed-wetting problems find it useful, as do many men with prostate problems (BPH). Vasopressindoesn't effect the prostate, ...
  • Preventing and Treating Men's Prostate Problems

    Preventing and Treating Men's Prostate Problems Benign Prostatic Hypertrophy (BPH) Near-Universal Malady in Men over 50 (with kind permission of Vitamin Research Products). Few men ever consider the walnut-sized gland located just below the bladder until it starts to give them trouble. In fact, a 1995 survey in the London Times found that 89% of the men surveyed did not know where the prostate was located! After the age of 50, the prostate begins to hypertrophy, o...
  • Deprenyl- A Multi-Functional Anti-aging Drug

      Deprenyl- A Multi-Functional Anti-aging Drug By Ward Dean MD   Deprenyl was developed by Professor Joseph Knoll of Semmelweiss University in Hungary in the early 1960's as a 'psychic energizer' and antidepressant (Knoll, et al, 1965). It was later found that when Deprenyl was administered in conjunction with other agents for Parkinson's disease, it significantly improved the results (Birkmayer, et al, 1977). Parkinson's is a debilitating illness, cha...
  • The Demonization of GHB by Ward Dean, M.D.

    The Demonization of GHB As Alabama proposes life in prison for possession of two ounces (sic), the GHB demonization reaches new heights of absurdity. One of my patients called recently to tell me that a bill was being introduced in the Alabama State Legislature this year that would make possession of 56 grams of GHB - about two ounces (and presumably also, GBL and 1,4 BD) punishable by life in prison without possibility of parole! The bill, sponsored by Sena...
  • The Classification Of GHB In The USA

    The Classification Of GHB In The USA The following is a collection of articles and communications from Ward Dean MD about the GHB situation in the United States. They include his communication with the various authorities and comments on his court appearances as an expert witness on behalf of the defense. The articles appear in the order of the latest first, so in some cases you may wish to read on to learn of some of the earlier links and references.Open Le...
  • GHB: Powerful Growth Hormone Secretagogue

    GHB: Powerful Growth Hormone Secretagogue Growth hormone is one of the many hormones that declines dramatically with age (Fig.1). Growth hormone has multiple functions in the body, including maintaining lean body mass, mobilizing fat, counteracting insulin, enhancing immunity, lowering blood pressure and improving cholesterol levels, increasing energy, and even improving vision. Many physicians now routinely prescribe growth hormone s...
  • Androstenedione - Is It A Big Hit?

    Androstenedione - Is It A Big Hit? Recently a new dietary supplement has taken the sports nutrition market by storm. Androstenedione, (pronounced "an-dro-stene-dye-own") is a metabolite of DHEA and a natural precursor of testosterone. To understand why androstenedione has become so popular with athletes and bodybuilders, as well as how it may benefit health in general, we first need to look at testosterone. Testosterone is responsible for the normal growth and developme...
  • A Review of the GHB Scientific Literature

    A Review of the GHB Scientific Literature GHB's history is unusual in that it was synthesized, (created in the laboratory) before it was discovered as a naturally-occurring molecule. This is the reverse of what typically occurs in science. The scientific study of GHB began in the early 1960s in Paris. Dr. Henri-Marie Laborit, who was then Director of the Laboratoire d'Eutonologie, Boucic ut Hospital, was interested in the function of the natural amino acid, butyric acid, in ...
  • Metformin: The most effective and under-appreciated life extension drug

    Metformin: The most effective and under-appreciated life extension drug Metformin, an anti-diabetic biguanide drug, has recently been introduced in the United States for the treatment of non-insulin dependent diabetes (type II diabetes). In addition to its promise in treating diabetes, metformin may prove to be one of the most promising anti-aging; life extending drugs available! Metformin is chemically very similar to phenformin, an anti-diabetic drug that was disconti...
  • Metformin: As a Safe, Effective Weight Loss Drug

      Metformin: The Most Effective Life Extension Drug is Also a Safe, Effective Weight Loss Drug   Metformin (Glucophage( ®)) is an anti-diabetic biguanide drug which is now available in the United States for the treatment of both Type I diabetes (insulin dependent) as well as Type II (non-insulin-dependent) diabetes. In addition to its dramatic ability to improve the condition of diabetics, ~Metformin is also one of the most promising anti-aging, life extendin...
  • Hydergine ® - Update - Still Highly Recommended

    Hydergine ® - Update - Still Highly Recommended Many life extension physicians and enthusiasts first learned of the concept of "smart drugs" from reading the blockbuster best-seller, Life Extension, A Practical Scientific Approach, by Durk Pearson and Sandy Shaw. Pearson and Shaw extolled the virtues of a drug called Hydergine ®- a Sandoz trademark (ergoloid mesylates), a combination of thre...
  • Acetyl-L-Carnitine - The Rejuvenating Effects

    The Rejuvenating Effects of Acetyl-L-Carnitine Dr. Dean is the Research Director of Vitamin Research Products and this article is reprinted from VRP's Nutritional News with their kind permission. To avail yourself of good nutritional information on a regular basis call VRP in Carson City, Nevada, USA on 800 877 2447. One of the most common characteristics of aging is a loss of energy, I am reminded of this dry scientific fact every day as I try to keep up with my two so...
  • Dr. Dean's most Recommended Anti-aging Medicine

    Dr. Dean's most Recommended Anti-aging Medicine Ward Dean, M.D., is one of the most forthright physicians in the world today who is researching and practising anti-aging medicine. Apart from his groundbreaking work with Professor Vladimir Dilman, in forming the; "Neuroendocrine Theory of Aging and Degenerative Disease," he is also a world renowned expert in; Biological Aging Measurement, having written the magnum opus of the same name. Well known for writin...
  • Acarbose - A Starch Blocking Anti-Diabetic Drug & Potential Weight Loss Agent

    Acarbose - A Starch Blocking Anti-Diabetic Drug & Potential Weight Loss Agent Insulin resistance is the central metabolic defect in a cluster of disorders now referred to as Syndrome X. This cluster of diseases includes Type II diabetes mellitus, obesity, hyperinsulinemia, hypertension, hyperlipidemia, and atherosclerosis. This syndrome was first described (in Russian) by Professor Vladimir Dilman in 1955. Today, Dilman's name is rarely mentioned as the first to have appreciat...